Adverse Effects of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine in 6- to 7-Year-Old Children

Although the safety profile of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines in adolescents and adults has been documented, few data have reported about their adverse events in children. Healthy 6- to 7-year-old children who were immunized with Tdap vaccine were...

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Main Authors: Sung-Hsi Wei (Author), Yen-Nan Chao (Author), Song-En Huang (Author), Tsuey-Feng Lee (Author), Luan-Yin Chang (Author)
Format: Book
Published: Elsevier, 2011-02-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Sung-Hsi Wei  |e author 
700 1 0 |a Yen-Nan Chao  |e author 
700 1 0 |a Song-En Huang  |e author 
700 1 0 |a Tsuey-Feng Lee  |e author 
700 1 0 |a Luan-Yin Chang  |e author 
245 0 0 |a Adverse Effects of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine in 6- to 7-Year-Old Children 
260 |b Elsevier,   |c 2011-02-01T00:00:00Z. 
500 |a 1875-9572 
500 |a 10.1016/j.pedneo.2010.12.010 
520 |a Although the safety profile of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines in adolescents and adults has been documented, few data have reported about their adverse events in children. Healthy 6- to 7-year-old children who were immunized with Tdap vaccine were evaluated for adverse events on Days 1, 2, 4, and 7 postimmunization. Information of sex, body mass index (BMI), and previous diphtheria-pertussis-tetanus (DPT) immunization history was obtained and evaluated for the association with the adverse events. A total of 243 6- to 7-year-old children were immunized with Tdap. Among the 243 children immunized, remarkable adverse events included redness more than or equal to 10 mm in 47 (19%) children, induration more than or equal to 10 mm in 57 (23%), tenderness in 130 (53%), and fever in 12 (5%). Redness and induration resolved in 7 days and fever resolved on Day 4. The adverse events were not associated with gender, BMI above the mean value, or the type of fourth DPT immunization. Adverse events after Tdap vaccination were mild and dissolved within 7 days in 6- to 7-year-old children. 
546 |a EN 
690 |a acellular pertussis 
690 |a adacel 
690 |a adverse events 
690 |a children 
690 |a reduced diphtheria toxoid 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Pediatrics and Neonatology, Vol 52, Iss 1, Pp 38-41 (2011) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S1875957210000185 
787 0 |n https://doaj.org/toc/1875-9572 
856 4 1 |u https://doaj.org/article/89cebf9bccd84a3a8ed88c77095b6c09  |z Connect to this object online.