Metformin Suppresses Hypopharyngeal Cancer Growth by Epigenetically Silencing Long Non-coding RNA SNHG7 in FaDu Cells

• Prif Awduron: Ping Wu (Awdur), Yaoyun Tang (Awdur), Xing Fang (Awdur), Chubo Xie (Awdur), Junfeng Zeng (Awdur), Wei Wang (Awdur), Suping Zhao (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Local recurrence after therapy remains a challenging problem for hypopharyngeal cancer (HPC) due to the chemotherapy resistance. Metformin is associated with reduced cancer risk through promoting global DNA methylation in cancer cells by controlling S-adenosylhomocysteine (SAHH) activity. However, t...