Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration

• Autores principales: Michael J. Tolentino (Autor), Andrew J. Tolentino (Autor), Elizabeth M. Tolentino (Autor), Anitha Krishnan (Autor), Mohamed A. Genead (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Age-related macular degeneration (AMD), a leading cause of visual loss and dysfunction worldwide, is a disease initiated by genetic polymorphisms that impair the negative regulation of complement. Proteomic investigation points to altered glycosylation and loss of Siglec-mediated glyco-immune checkp...