Heart Rate Predicts the Risk of New-Onset Peripheral Arterial Disease in a Community-Based Population in China

• Main Authors: Gao Y (Author), Fan F (Author), Jia J (Author), Jiang Y (Author), He D (Author), Wu Z (Author), Huo Y (Author), Zhou J (Author), Zhang Y (Author)
• Format: Book
• Published: Dove Medical Press, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1178-203X
• Keywords: cohort studies; heart rate; peripheral arterial disease; ankle-brachial index; Therapeutics. Pharmacology; RM1-950
• Source: Therapeutics and Clinical Risk Management, Vol Volume 17, Pp 267-274 (2021)

Yusi Gao, Fangfang Fan, Jia Jia, Yimeng Jiang, Danmei He, Zhongli Wu, Yong Huo, Jing Zhou, Yan Zhang Department of Cardiology, Peking University First Hospital, Beijing, People&rsquo;s Republic of ChinaCorrespondence: Jing ZhouDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, People&rsquo;s Republic of ChinaTel [phone]Fax [phone]Email [e-mail]: Elevated heart rate is linked with poor prognosis and has been shown to accelerate the progress of atherosclerosis. However, the association between heart rate and new-onset PAD is unknown.Methods: A total of 3463 participants without PAD at baseline from a community-based cohort in Beijing were included and followed up for 2.3 years. PAD was defined as ankle&ndash;brachial index (ABI) &le; 0.9. We used multivariate logistic regression models to investigate the association of heart rate and the risk of new-onset PAD.Results: Participants were 56.67 &plusmn; 8.54 years old, and 36.12% were men. The baseline ABI was 1.11 &plusmn; 0.08, and the incidence of new-onset PAD was 2.97%. Multivariate regression models, adjusted for sex, age, risk factor of atherosclerosis, medications, and baseline ABI, showed that heart rate was significantly associated with incidence of PAD (odds ratio [OR] = 1.22, 95% confidence interval [CI]: 1.03&ndash; 1.43, P = 0.020); every increase of 10 heart beats per minute (bpm) was associated with a 22% increase in the odds of developing new-onset PAD. Respondents in the higher-heart rate group (&ge; 80 bpm) had an increased risk of new-onset PAD, compared with those in the lower-heart rate group (< 80 bpm) (OR = 1.73, 95% CI: 1.14&ndash; 2.63, P = 0.010). Subgroup analyses revealed no significant heterogeneity among the analyzed subgroups.Conclusion: Elevated heart rate was independently associated with the risk of new-onset PAD in a community-based population in Beijing. Heart rate management should be considered for the purpose of PAD prevention.Keywords: cohort studies, heart rate, peripheral arterial disease, ankle&ndash;brachial index