Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change

The mitochondrion is an important organelle and provides energy for a plethora of intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and alteration in metabolism has been identified in multiple disease states-cancer being one. Otto Warburg demonstrated that cancer c...

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Main Authors: Zhengqiu Zhou (Author), Elochukwu Ibekwe (Author), Yevgen Chornenkyy (Author)
Format: Book
Published: MDPI AG, 2018-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Zhengqiu Zhou  |e author 
700 1 0 |a Elochukwu Ibekwe  |e author 
700 1 0 |a Yevgen Chornenkyy  |e author 
245 0 0 |a Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change 
260 |b MDPI AG,   |c 2018-01-01T00:00:00Z. 
500 |a 2076-3921 
500 |a 10.3390/antiox7010016 
520 |a The mitochondrion is an important organelle and provides energy for a plethora of intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and alteration in metabolism has been identified in multiple disease states-cancer being one. Otto Warburg demonstrated that cancer cells, in the presence of oxygen, undergo glycolysis by reprogramming their metabolism-termed "aerobic glycolysis". Alterations in metabolism enable cancer cells to gain a growth advantage by obtaining precursors for macromolecule biosynthesis, such as nucleic acids and lipids. To date, several molecules, termed "oncometabolites", have been identified to be elevated in cancer cells and arise from mutations in nuclear encoded mitochondrial enzymes. Furthermore, there is evidence that oncometabolites can affect mitochondrial dynamics. It is believed that oncometabolites can assist in reprogramming enzymatic pathways and providing cancer cells with selective advantages. In this review, we will touch upon the effects of normal and aberrant mitochondrial metabolism in normal and cancer cells, the advantages of metabolic reprogramming, effects of oncometabolites on metabolism and mitochondrial dynamics and therapies aimed at targeting oncometabolites and metabolic aberrations. 
546 |a EN 
690 |a mitochondria 
690 |a oncometabolites 
690 |a cancer 
690 |a metabolic re-programming 
690 |a aerobic glycolysis 
690 |a mitochondrial dynamics 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 7, Iss 1, p 16 (2018) 
787 0 |n http://www.mdpi.com/2076-3921/7/1/16 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/8a04480895d4470dbeef2bc9a1b79aef  |z Connect to this object online.