Darier disease with acrokeratosis verruciformis of hopf and their aggravation on lithium therapy for bipolar disorder
Darier disease (DD) and acrokeratosis verruciformis of Hopf are rare autosomal dominant skin disorders. Both are caused by a single gene mutation, i.e., ATP2A2 located on chromosome 12, which is expressed in the skin and brain. However, both the diseases are clinically and histopathologically distin...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Book |
| Published: |
Wolters Kluwer Medknow Publications,
2023-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Darier disease (DD) and acrokeratosis verruciformis of Hopf are rare autosomal dominant skin disorders. Both are caused by a single gene mutation, i.e., ATP2A2 located on chromosome 12, which is expressed in the skin and brain. However, both the diseases are clinically and histopathologically distinct. DD is associated with many neuropsychiatric conditions such as depression, bipolar disorder (BPD), and seizures. Lithium is commonly used as a mood stabilizer in psychiatry and is reported to aggravate DD. We report a case of a 17-year-old female with DD and acrokeratosis verruciformis with associated with BPD Type 1 presenting with an aggravation of skin lesions after starting lithium therapy. |
|---|---|
| Item Description: | 2319-7250 10.4103/ijpd.ijpd_60_22 |