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Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment

MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this study, a novel series of dual MDH1/2 inhibitors for lung cancer was rationally designed and synthesized, and their SAR was carefully investigated. Among the tested compounds, compound <b>50</b> containin...

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Main Authors: Sreenivasulu Godesi (Author), Jeong-Ran Han (Author), Jang-Keun Kim (Author), Dong-Ik Kwak (Author), Joohan Lee (Author), Hossam Nada (Author), Minkyoung Kim (Author), Hyun-A Yang (Author), Joo-Young Im (Author), Hyun Seung Ban (Author), Chang Hoon Lee (Author), Yongseok Choi (Author), Misun Won (Author), Kyeong Lee (Author)
Format: Book
Published: MDPI AG, 2023-05-01T00:00:00Z.
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