Piperacillin enhances the inhibitory effect of tazobactam on β-lactamase through inhibition of organic anion transporter 1/3 in rats

• Main Authors: Shilei Yang (Author), Zhihao Liu (Author), Changyuan Wang (Author), Shijie Wen (Author), Qiang Meng (Author), Xiaokui Huo (Author), Huijun Sun (Author), Xiaodong Ma (Author), Jinyong Peng (Author), Zhonggui He (Author), Kexin Liu (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To assess the mechanism of the pharmacokinetic interaction between piperacillin and tazobactam, renal excretion and pharmacokinetic studies of piperacillin/tazobactam were investigated in normal and bacteremia rats. A bacteremia model was established to investigate the pharmacokinetic properties of...