Detection of aggressive periodontitis by calprotectin expression

• Main Authors: Desi Sandra Sari (Author), Suryono Suryono (Author)
• Format: Book
• Published: Universitas Airlangga, 2009-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1978-3728; 2442-9740; 10.20473/j.djmkg.v42.i4.p185-188
• Keywords: Calprotectin; aggressive periodontitis; gingival crevicular fluids; Dentistry; RK1-715
• Source: Dental Journal, Vol 42, Iss 4, Pp 185-188 (2009)

<span style="font-family: Tribune-Bold; font-size: 10pt; color: #231f20; font-style: normal; font-variant: normal;"><strong>Background: </strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>Calprotectin is a calcium-binding protein expressed by neutrophil, monocytes, gingival keratinocytes, and oral </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>epithelial cells. The concentrations of calprotectin increase in plasma, urine and synovial fluid of patients with inflammatory diseases. </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>This protein is known as a marker for periodontal diseases and is detected in gingival crevicular fluids. </em><span style="font-family: Tribune-Bold; font-size: 10pt; color: #231f20; font-style: normal; font-variant: normal;"><strong>Purpose: </strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>This study was aimed </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>to investigate the detection of inflammation on the aggressive periodontitis by calprotectin expression. </em><span style="font-family: Tribune-Bold; font-size: 10pt; color: #231f20; font-style: normal; font-variant: normal;"><strong>Method: </strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>The gingival crevicular </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>fluids were taken from five aggressive periodontitis patients and five healthy subjects by using sterile paper points. Calprotectin </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>expression was analyzed by ELISA technique. </em><span style="font-family: Tribune-Bold; font-size: 10pt; color: #231f20; font-style: normal; font-variant: normal;"><strong>Result</strong><span style="font-family: Tribune-Bold; font-size: 10pt; color: #0000ff; font-style: normal; font-variant: normal;"><strong>: </strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>The results showed the significant difference in calprotectin expression between </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>subject with aggressive periodontitis and healthy subjects p = 0.002 (p < 0.05)</em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #0000ff; font-style: normal; font-variant: normal;"><em>. </em><span style="font-family: Tribune-Bold; font-size: 10pt; color: #231f20; font-style: normal; font-variant: normal;"><strong>Conclusion: </strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>It was concluded that the calprotectin </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>expression on the aggressive periodontitis patients may be useful for evaluation the progression of inflammation in periodontitis.</em></span></span></span></span></span></span></span><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /></span></span></span></span></span></span></span></span></span></span></span></span>