Efficacy, safety, and correlative biomarkers of bintrafusp alfa in recurrent or metastatic nasopharyngeal cancer patients: a phase II clinical trialResearch in context

• Main Authors: Chi Leung Chiang (Author), Tai Chung Lam (Author), James Chun Bong Li (Author), Kenneth Sik Kwan Chan (Author), Aya El Helali (Author), Yolanda Yim Ping Lee (Author), Laalaa Hiu Ting Law (Author), Danyang Zheng (Author), Anthony Wing Ip Lo (Author), Ngar Woon Kam (Author), Wing Sum Li (Author), Alice Ka Wai Cheung (Author), James Chung Hang Chow (Author), Sunny Po Chung Chan (Author), Jessica Wing Yu Lai (Author), Sarah Wai Man Lee (Author), Feng-Ming (Spring) (Author), Wai Tong Ng (Author), Dora Lai Wan Kwong (Author), Anne Wing Mui Lee (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: The strategy of dual blockade of TGF-β and PD-L1 pathways has not been previously tested in platinum-refractory recurrent or metastatic nasopharyngeal cancer (R/M NPC) patients. This study aimed to evaluate the safety and efficacy of bintrafusp alfa in refractory R/M NPC patient...