Association between paraoxonase gene and stroke in the Han Chinese population

• Main Authors: Zhang Guojun (Author), Li Wenjin (Author), Li Zhiqiang (Author), Lv Hong (Author), Ren Yonghong (Author), Ma Ruimin (Author), Li Xiaohong (Author), Kang Xixiong (Author), Shi Yongyong (Author), Sun Yimin (Author)
• Format: Book
• Published: BMC, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>The human paraoxonase (<it>PON</it>) gene family has three isoforms: <it>PON1</it>, <it>PON2</it> and <it>PON3</it>. These genes are implicated as potential risk factors of cerebrovascular disease and can prevent oxidative modification of low-density lipoproteins and atherosclerosis. This study evaluated the association between the genetic variants of all three <it>PON</it> genes and the risks of total stroke, ischemic stroke and hemorrhagic stroke in the Han Chinese population.</p> <p>Methods</p> <p>A total of 1016 subjects were recruited, including 508 healthy controls and 498 patients (328 with ischemic stroke and 170 with hemorrhagic stroke). A total of 11 single nucleotide polymorphisms (SNPs) covering the <it>PON</it> genes were genotyped for statistical analysis. Two of the 11 SNPs (rs662 and rs854560) were contextualized in a meta-analysis of ischemic stroke.</p> <p>Results</p> <p>The presence of rs705381 (−162) in the promoter region of <it>PON1</it> was significantly associated with total stroke (<it>P</it>_{<it>adjusted</it>} = 0.0007, <it>OR</it> = 0.57 [95% CI = 0.41-0.79]) and ischemic stroke (<it>P</it>_{<it>adjusted</it>} = 0.0017, <it>OR</it> = 0.54 [95% CI = 0.37-0.79]) when analyzed using a dominant model, but was not associated with hemorrhagic stroke. There was also a nominal association between rs854571 (−824) and total stroke. Meta-analysis demonstrated a significant nominal association between rs662 and ischemic stroke, but there was no evidence of an association between rs662 and ischemic stroke risk in a single site association study.</p> <p>Conclusions</p> <p>These findings indicate that polymorphisms of <it>PON1</it> gene may be a risk factor of stroke.</p>

Item Description

10.1186/1471-2350-14-16
1471-2350