Potentially active aspirin derivative to release nitric oxide: In-vitro, in-vivo and in-silico approaches

• Main Authors: Amruta M. Amritkar (Author), Afzal Hussain (Author), Mohammad A. Altamimi (Author), Sumel Ashique (Author), Mohd Usman Mohd Siddique (Author), Sushil Burle (Author), Anwar R. Shaikh (Author), Sameer N. Goyal (Author), Zahid R. Bhat (Author)
• Format: Bog
• Udgivet: Elsevier, 2024-03-01T00:00:00Z.
• Fag: article
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The series of newer salicylate derivatives incorporating nitroxy functionality were synthesized and evaluated for their potential effect in gastrointestinal (GI) related toxicity produced by aspirin. The synthesized compounds (5a-j) were subjected to %NO (nitric oxide) release study, in-vitro anti-i...