A multi-centre, open label, randomised, parallel-group, superiority Trial to compare the efficacy of URsodeoxycholic acid with RIFampicin in the management of women with severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC randomised trial

• Main Authors: William M. Hague (Author), Leonie Callaway (Author), Jennifer Chambers (Author), Lucy Chappell (Author), Suzette Coat (Author), Jiska de Haan-Jebbink (Author), Marloes Dekker (Author), Peter Dixon (Author), Jodie Dodd (Author), Maria Fuller (Author), Sanne Gordijn (Author), Dorothy Graham (Author), Oskari Heikinheimo (Author), Annemarie Hennessy (Author), Risto Kaaja (Author), Teck Yee Khong (Author), Laura Lampio (Author), Jennie Louise (Author), Angela Makris (Author), Corey Markus (Author), Hanns-Ulrich Marschall (Author), Philippa Middleton (Author), Ben W. Mol (Author), Jonathan Morris (Author), John P. Newnham (Author), Caroline Ovadia (Author), Michael Peek (Author), Antonia Shand (Author), Michael Stark (Author), Jim Thornton (Author), Susanna Timonen (Author), Susan Walker (Author), David Warrilow (Author), Catherine Williamson (Author)
• Format: Book
• Published: BMC, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Severe early onset (less than 34 weeks gestation) intrahepatic cholestasis of pregnancy (ICP) affects 0.1% of pregnant women in Australia and is associated with a 3-fold increased risk of stillbirth, fetal hypoxia and compromise, spontaneous preterm birth, as well as increased fr...