Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and pannus formation, which can lead to severe destruction of cartilage and bone. Several self proteins have been suggested to be disease-driving autoantigens. Moreover the presence of autoantibodies t...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
PAGEPress Publications,
2011-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and pannus formation, which can lead to severe destruction of cartilage and bone. Several self proteins have been suggested to be disease-driving autoantigens. Moreover the presence of autoantibodies to citrullinated proteins in sera of patients with RA enhances the strength of this hypothesis. Proteins are encoded by a limited number of genes in our genome. Post-translational modifications such as phosphorylation, glycosylation and citrullination can increase the morphological and the functional diversity of the proteome. |
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| Item Description: | 10.4081/reumatismo.2008.85 0048-7449 2240-2683 |