High grade sarcoma with chondrosarcomatous differentiation in primary uterine leiomyosarcoma; A rare case and review of literature
Primary uterine leiomyosarcoma (LMS) with chondrosarcomatous differentiation is extremely rare. We report a case of a 68-year-old, African American woman who presented with postmenopausal bleeding. Ultrasonography (USG) revealed multiple uterine fibroids. Total abdominal hysterectomy with bilateral...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
Elsevier,
2022-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Primary uterine leiomyosarcoma (LMS) with chondrosarcomatous differentiation is extremely rare. We report a case of a 68-year-old, African American woman who presented with postmenopausal bleeding. Ultrasonography (USG) revealed multiple uterine fibroids. Total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH/BSO) was performed. Microscopic examination of the largest intramural nodule showed high-grade sarcoma, comprising of LMS with a focal transformation to undifferentiated sarcoma with chondrosarcomatous differentiation. Endometrium was benign excluding carcinosarcoma. Heterologous differentiation has rarely been described in metastatic or recurrent uterine LMS; however, a primary uterine LMS with chondrosarcomatous differentiation has not been reported previously. |
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| Item Description: | 2352-5789 10.1016/j.gore.2021.100905 |