High grade sarcoma with chondrosarcomatous differentiation in primary uterine leiomyosarcoma; A rare case and review of literature

Primary uterine leiomyosarcoma (LMS) with chondrosarcomatous differentiation is extremely rare. We report a case of a 68-year-old, African American woman who presented with postmenopausal bleeding. Ultrasonography (USG) revealed multiple uterine fibroids. Total abdominal hysterectomy with bilateral...

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Main Authors: Qandeel Sadiq (Author), Farhan Khan (Author)
Format: Book
Published: Elsevier, 2022-02-01T00:00:00Z.
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100 1 0 |a Qandeel Sadiq  |e author 
700 1 0 |a Farhan Khan  |e author 
245 0 0 |a High grade sarcoma with chondrosarcomatous differentiation in primary uterine leiomyosarcoma; A rare case and review of literature 
260 |b Elsevier,   |c 2022-02-01T00:00:00Z. 
500 |a 2352-5789 
500 |a 10.1016/j.gore.2021.100905 
520 |a Primary uterine leiomyosarcoma (LMS) with chondrosarcomatous differentiation is extremely rare. We report a case of a 68-year-old, African American woman who presented with postmenopausal bleeding. Ultrasonography (USG) revealed multiple uterine fibroids. Total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH/BSO) was performed. Microscopic examination of the largest intramural nodule showed high-grade sarcoma, comprising of LMS with a focal transformation to undifferentiated sarcoma with chondrosarcomatous differentiation. Endometrium was benign excluding carcinosarcoma. Heterologous differentiation has rarely been described in metastatic or recurrent uterine LMS; however, a primary uterine LMS with chondrosarcomatous differentiation has not been reported previously. 
546 |a EN 
690 |a Uterine leiomyosarcoma 
690 |a Undifferentiated sarcoma 
690 |a Chondrosarcomatous differentiation 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
690 |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens 
690 |a RC254-282 
655 7 |a article  |2 local 
786 0 |n Gynecologic Oncology Reports, Vol 39, Iss , Pp 100905- (2022) 
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