Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates

• Main Authors: Bing Zhao (Author), Xinhui Zhang (Author), Tingting Yu (Author), Ying Liu (Author), Xiaoling Zhang (Author), Yongfang Yao (Author), Xuejian Feng (Author), Hongmin Liu (Author), Dequan Yu (Author), Liying Ma (Author), Shangshang Qin (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New Delhi metallo-β-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all β-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive "superbug", and no promising NDM-1 inhibitors were used in clinica...