Design and Synthesis of Hybrid Compounds as Epigenetic Modifiers

• Main Authors: Juliana Romano Lopes (Author), Igor Muccilo Prokopczyk (Author), Max Gerlack (Author), Chung Man Chin (Author), Jean Leandro Dos Santos (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic modifiers acting through polypharmacology mechanisms are promising compounds with which to treat several infectious diseases. Histone deacetylase (HDAC) enzymes, mainly class I, and extra-terminal bromodomains (BET) are involved in viral replication and the host response. In the present s...