Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies

• Main Authors: Gwo-Yu Chuang (Author), Mangaiarkarasi Asokan (Author), Vera B. Ivleva (Author), Amarendra Pegu (Author), Eun Sung Yang (Author), Baoshan Zhang (Author), Rajoshi Chaudhuri (Author), Hui Geng (Author), Bob C. Lin (Author), Mark K. Louder (Author), Krisha McKee (Author), Sijy O'Dell (Author), Hairong Wang (Author), Tongqing Zhou (Author), Nicole A. Doria-Rose (Author), Lisa A. Kueltzo (Author), Q. Paula Lei (Author), John R. Mascola (Author), Peter D. Kwong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Broadly neutralizing antibodies are showing promise in the treatment and prevention of HIV-1, with several now being evaluated clinically. Some lead clinical candidates, including antibodies CAP256-VRC26.25, N6, PGT121, and VRC07-523, have one or more N-linked glycosylation sequons in their variable...