The Release of Diazepam from Different Conventional and Hollow Type Suppository Bases

• Main Author: Balkis A. Kamal (Author)
• Format: Book
• Published: College of Pharmacy University of Baghdad, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.31351/vol16iss2pp21-26; 2521-3512; 1683-3597
• Keywords: Pharmacy and materia medica; RS1-441
• Source: Iraqi Journal of Pharmaceutical Sciences, Vol 16, Iss 2 (2017)

The objective of this study was to investigate the release profile of different fat and water soluble bases using diazepam as a model drug , and then to develop a satisfactory formula with a rapid release of diazepam from suppository bases .The study was conducted using theobroma oil ,glycerol-gelatin and glycerol-PEG1540 bases using conventional mold method for preparation .while the later base was utilized to incorporate diazepam ( buffered solution ) in a hollow type suppositories. The results indicated that all types of bases can be utilized to formulate diazepam as rectal suppositories with acceptable disintegration time ( 12, 10, 6, and 6min.), respectively . While 100% of the released drug had been shown different release profiles with different storage time ( 15, 30, and 45 days ) in a refrigerator at 5°C , best results were obtained , when glycerol- PEG1540 used as a base for both conventional and hollow type mold methods .However , a decrease in the release rate of the drug was seen with glycerol-gelatin and glycerol-PEG1540 and to a lesser extent for glycerol-PEG1540 prepared by hollow type method . Key words: Diazepam , Hollow type suppository