Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study

• Main Authors: Hari V. Kalluri (Author), Ryota Kikuchi (Author), Sheryl Coppola (Author), Jeffrey Schmidt (Author), Mohamed‐Eslam F. Mohamed (Author), Daniel A.J. Bow (Author), Ahmed H. Salem (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are involved in the disposition of a variety of commonly prescribed drugs. The evaluation of OATP1B1/1B3 inhibition potential by investigational drugs is of interest during clinical drug development due to various adverse events associate...