The Genomic and Structural Organization of SARS-CoV-2: A Mutational Perspective
The ongoing pandemic due to the novel SARS-CoV-2 disease (COVID-19) has exerted a great toll on human health. The SARS-CoV-2 is the third most pathogenic human CoV after SARS-CoV-1 and MERS-CoV, which is classified within the genus Betacoronavirus. Though the actual source of its origin and transmis...
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2021-03-01T00:00:00Z.
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| 001 | doaj_8b59a53e70b5487b90634b7932c48412 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mohammad K. Parvez |e author |
| 700 | 1 | 0 | |a Sakina Niyazi |e author |
| 245 | 0 | 0 | |a The Genomic and Structural Organization of SARS-CoV-2: A Mutational Perspective |
| 260 | |b Ital Publication, |c 2021-03-01T00:00:00Z. | ||
| 500 | |a 2704-9833 | ||
| 500 | |a 10.28991/SciMedJ-2021-0301-8 | ||
| 520 | |a The ongoing pandemic due to the novel SARS-CoV-2 disease (COVID-19) has exerted a great toll on human health. The SARS-CoV-2 is the third most pathogenic human CoV after SARS-CoV-1 and MERS-CoV, which is classified within the genus Betacoronavirus. Though the actual source of its origin and transmission is still unclear, genetic analysis has shown its very close similarity (~96%) with bat SARS-like CoV. SARS-CoV-2 is a spherically-icosahedral virus with a plus-sense single-strand RNA (~30 kb) genome defined into thirteen open reading frames, which encode 2 non-structural polyproteins, 4 structural proteins and 6 accessory proteins. Of its structural proteins the 'S1' subunit of spike (S) contains the cellular ACE-2 receptor binding domain (RBD) whereas the 'S2' subunit is required for cell membrane fusion. The membrane (M) protein participates in cell-fusion whereas envelope (E) is necessary for virion assembly and morphogenesis. The non-structural polyproteins (pp1a and pp1b) undergo proteolytic processing to produce a total of 16 small proteins, which are involved in mRNA synthesis and replication. Of the accessory proteins (3a, 6, 7a, 7b, 8 and 9b), few are known to modulate host-innate immunity. Interestingly, '3b' is absent in SARS-CoV-2 that significantly differentiates it from other human CoV. Detection of several novel mutations in '3a', '3b' and 'ORF8' proteins, notably in the 'S' RBD strongly suggest SARS-CoV-2 enhanced cell attachment and facilitated entry, its high infectivity and disease severity in humans. The recent emergence of highly contagious SARS-CoV-2 RBD variants in the United Kingdom (B.1.1.7 strain), South Africa (B.1.351 strain) and Brazil (P.1 strain), and their subsequent spread to other counties have raised serious concerns. Doi: 10.28991/SciMedJ-2021-0301-8 Full Text: PDF | ||
| 546 | |a EN | ||
| 690 | |a coronavirus | ||
| 690 | |a severe acute respiratory syndrome | ||
| 690 | |a sars-cov-2 | ||
| 690 | |a covid-19 | ||
| 690 | |a ace-2 | ||
| 690 | |a mutations. | ||
| 690 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | ||
| 690 | |a RC254-282 | ||
| 690 | |a Public aspects of medicine | ||
| 690 | |a RA1-1270 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n SciMedicine Journal, Vol 3, Iss 1, Pp 59-65 (2021) | |
| 787 | 0 | |n https://www.scimedjournal.org/index.php/SMJ/article/view/273 | |
| 787 | 0 | |n https://doaj.org/toc/2704-9833 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8b59a53e70b5487b90634b7932c48412 |z Connect to this object online. |