Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Background: The gut microbiome influences host physiology and cardiometabolic diseases by interacting directly with intestinal cells or by producing molecules that enter the host circulation. Given the large number of microbial species present in the gut and the numerous factors that influence gut b...

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Main Authors: Yang Cao (Author), Ruben Aquino-Martinez (Author), Evan Hutchison (Author), Hooman Allayee (Author), Aldons J. Lusis (Author), Federico E. Rey (Author)
Format: Book
Published: Elsevier, 2022-10-01T00:00:00Z.
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100 1 0 |a Yang Cao  |e author 
700 1 0 |a Ruben Aquino-Martinez  |e author 
700 1 0 |a Evan Hutchison  |e author 
700 1 0 |a Hooman Allayee  |e author 
700 1 0 |a Aldons J. Lusis  |e author 
700 1 0 |a Federico E. Rey  |e author 
245 0 0 |a Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach 
260 |b Elsevier,   |c 2022-10-01T00:00:00Z. 
500 |a 2212-8778 
500 |a 10.1016/j.molmet.2022.101557 
520 |a Background: The gut microbiome influences host physiology and cardiometabolic diseases by interacting directly with intestinal cells or by producing molecules that enter the host circulation. Given the large number of microbial species present in the gut and the numerous factors that influence gut bacterial composition, it has been challenging to understand the underlying biological mechanisms that modulate risk of cardiometabolic disease. Scope of the Review: Here we discuss a systems-based approach that involves simultaneously examining individuals in populations for gut microbiome composition, molecular traits using "omics" technologies, such as circulating metabolites quantified by mass spectrometry, and clinical traits. We summarize findings from landmark studies using this approach and discuss future applications. Major Conclusions: Population-based integrative approaches have identified a large number of microbe-derived or microbe-modified metabolites that are associated with cardiometabolic traits. The knowledge gained from these studies provide new opportunities for understanding the mechanisms involved in gut microbiome-host interactions and may have potentially important implications for developing novel therapeutic approaches. 
546 |a EN 
690 |a cardiometabolic diseases 
690 |a systems genetics 
690 |a gut microbiome 
690 |a metabolomics 
690 |a Internal medicine 
690 |a RC31-1245 
655 7 |a article  |2 local 
786 0 |n Molecular Metabolism, Vol 64, Iss , Pp 101557- (2022) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2212877822001260 
787 0 |n https://doaj.org/toc/2212-8778 
856 4 1 |u https://doaj.org/article/8b79e965969e4bd3b8f2433dde9e47c2  |z Connect to this object online.