Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma

Background: Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in cholangiocarcinoma. Therefore, we aimed to assess the prognostic value of tumor budding in intrahepatic and extrahepatic cholang...

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Main Authors: Kyung Bin Kim (Author), Ji Hyun Ahn (Author), Soon Wook Kwon (Author), Su Ji Lee (Author), Yury Lee (Author), Seo Young Park (Author), Ahrong Kim (Author), Kyung Un Choi (Author), Chang Hun Lee (Author), Gi Yeong Huh (Author)
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Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Kyung Bin Kim  |e author 
700 1 0 |a Ji Hyun Ahn  |e author 
700 1 0 |a Soon Wook Kwon  |e author 
700 1 0 |a Su Ji Lee  |e author 
700 1 0 |a Yury Lee  |e author 
700 1 0 |a Seo Young Park  |e author 
700 1 0 |a Ahrong Kim  |e author 
700 1 0 |a Ahrong Kim  |e author 
700 1 0 |a Kyung Un Choi  |e author 
700 1 0 |a Kyung Un Choi  |e author 
700 1 0 |a Chang Hun Lee  |e author 
700 1 0 |a Chang Hun Lee  |e author 
700 1 0 |a Gi Yeong Huh  |e author 
700 1 0 |a Gi Yeong Huh  |e author 
245 0 0 |a Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma 
260 |b Frontiers Media S.A.,   |c 2023-05-01T00:00:00Z. 
500 |a 1532-2807 
500 |a 10.3389/pore.2023.1611216 
520 |a Background: Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in cholangiocarcinoma. Therefore, we aimed to assess the prognostic value of tumor budding in intrahepatic and extrahepatic cholangiocarcinomas and to evaluate its correlations with other clinicopathological parameters.Methods: We monitored 219 patients who underwent surgery for intrahepatic or extrahepatic cholangiocarcinoma at the Pusan National University Hospital between 2012 and 2021. Tumor budding was evaluated using the International Tumor Budding Consensus Conference scoring system. Tumor budding was classified into low (0-4), intermediate (5-9), and high (≥10). For statistical analysis, tumor budding was divided into two groups based on the cut-off value of 10 (lower: 0-9 vs. higher: ≥10). The correlations between clinicopathological parameters were examined using the chi-square and Fisher's exact test. The prognostic values of the variables were analyzed using the log-rank test and Cox regression analysis.Results: Low, intermediate, and high tumor buddings were identified in 135 (61.6%), 63 (28.8), and 21 (9.6%), patients, respectively. Higher tumor budding was related to the presence of lymphatic invasion (p = 0.017), higher tumor grade (p = 0.001), higher N category (p = 0.034). In the univariable and multivariable analyses, higher tumor budding was associated with shorter disease-free survival in 97 (44.3%) patients who underwent R0 resection (p < 0.001 and p = 0.011). Tumor budding did not significantly correlate with disease-specific survival in entire patients.Conclusion: Tumor budding may serve as a prognostic factor for intrahepatic and extrahepatic cholangiocarcinomas treated with R0 resection. 
546 |a EN 
690 |a prognosis 
690 |a cholangiocarcinoma 
690 |a tumor budding 
690 |a prediction 
690 |a disease-free survival 
690 |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens 
690 |a RC254-282 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Pathology and Oncology Research, Vol 29 (2023) 
787 0 |n https://www.por-journal.com/articles/10.3389/pore.2023.1611216/full 
787 0 |n https://doaj.org/toc/1532-2807 
856 4 1 |u https://doaj.org/article/8b7ec3f33ef14f3da73c2560ab1c9a3d  |z Connect to this object online.