Cover Image

Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is one of the most frequent cancers worldwide, yet effective treatment remains a clinical challenge. Guaiazulene (GYZ), a cosmetic color additive, has previously been characterized as a potential antitumor agent due to observed anticancer effects. However, the effi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qin Ye (Author), Li Zhou (Author), Ping Jin (Author), Lei Li (Author), Shuwen Zheng (Author), Zhao Huang (Author), Jiayang Liu (Author), Siyuan Qin (Author), Hao Liu (Author), Bingwen Zou (Author), Ke Xie (Author)
Format:	Book
Published:	Frontiers Media S.A., 2021-04-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence
by: Marchal JA, et al.
Published: (2013)

A novel mechanism of 6-methoxydihydroavicine in suppressing ovarian carcinoma by disrupting mitochondrial homeostasis and triggering ROS/ MAPK mediated apoptosis
by: Huachang Zhang, et al.
Published: (2023)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
by: Yuan YL, et al.
Published: (2019)

Luteolin Protects Pancreatic β Cells against Apoptosis through Regulation of Autophagy and ROS Clearance
by: Ming Han, et al.
Published: (2023)

Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy
by: Yanan Li, et al.
Published: (2021)

A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer
by: Chengcheng Gao, et al.
Published: (2020)

Sodium Selenite Induces Autophagy and Apoptosis in Cervical Cancer Cells via Mitochondrial ROS-Activated AMPK/mTOR/FOXO3a Pathway
by: Cunqi Lv, et al.
Published: (2024)

Traditional Uyghur medicine Quercus infectoria galls water extract triggers apoptosis and autophagic cell death in colorectal cancer cells
by: Hui Zhang, et al.
Published: (2020)

A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells
by: Xiuli Dan, et al.
Published: (2016)

Lysosome Depletion-Triggered Autophagy Impairment in Progressive Kidney Injury
by: Xiao-cui Chen, et al.
Published: (2021)

Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo
by: Lei Yu, et al.
Published: (2021)

Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma
by: Ningna Weng, et al.
Published: (2022)

Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
by: Lixia Dong, et al.
Published: (2023)

Oxalate-induced apoptosis through ERS-ROS-NF-κB signalling pathway in renal tubular epithelial cell
by: Shaoxiong Ming, et al.
Published: (2022)

PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways
by: Huiai Lu, et al.
Published: (2021)

Linking ROS Levels to Autophagy: The Key Role of AMPK
by: Francesco Agostini, et al.
Published: (2023)

"NIR-triggered ROS storage" photodynamic intraocular implant for high-efficient and safe posterior capsular opacification prevention
by: Yanjuan Huang, et al.
Published: (2022)

Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation
by: Wang S, et al.
Published: (2020)

Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening
by: Dahong Yao, et al.
Published: (2020)

<i>Calocedrus formosana</i> Essential Oils Induce ROS-Mediated Autophagy and Apoptosis by Targeting SIRT1 in Colon Cancer Cells
by: Atikul Islam, et al.
Published: (2024)

ROS/JNK/C-Jun Pathway is Involved in Chaetocin Induced Colorectal Cancer Cells Apoptosis and Macrophage Phagocytosis Enhancement
by: Huihui Wang, et al.
Published: (2021)

Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys
by: Merlin Airik, et al.
Published: (2023)

Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells
by: Joo-Heon Kim, et al.
Published: (2019)

GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells
by: Hao Liu, et al.
Published: (2024)

Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy
by: Yacong Ji, et al.
Published: (2024)

miR-26 Induces Apoptosis and Inhibits Autophagy in Non-small Cell Lung Cancer Cells by Suppressing TGF-β1-JNK Signaling Pathway
by: Yi He, et al.
Published: (2019)

Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway
by: Xiang Qin, et al.
Published: (2022)

4-Hydroxyisoleucine inhibits tumor growth by triggering endoplasmic reticulum stress and autophagy
by: Peng Li, et al.
Published: (2022)

Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review
by: Ze Fu, et al.
Published: (2023)

Assay technologies for apoptosis and autophagy
by: Chitra Hariharan, et al.
Published: (2021)

The Phenoxyphenol Compound diTFPP Mediates Exogenous C<sub>2</sub>-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells
by: Wen-Tsan Chang, et al.
Published: (2021)

Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS-mediated signaling pathways
by: Jian Liu, et al.
Published: (2024)

Protective Effect of Qiliqiangxin against Doxorubicin-Induced Cardiomyopathy by Suppressing Excessive Autophagy and Apoptosis
by: Yating Qin, et al.
Published: (2022)

Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats
by: Kai-Kai Zhang, et al.
Published: (2021)

HSPB1 Regulates Autophagy and Apoptosis in Vascular Smooth Muscle Cells in Arteriosclerosis Obliterans
by: Keqin Chen, et al.
Published: (2022)

Population pharmacokinetics and exposure-response analyses of SAF-189s in Chinese patients with ALK+/ROS1+ non-small cell lung cancer
by: Yinhui Liu, et al.
Published: (2024)

Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes
by: Chenshu Liu, et al.
Published: (2023)

The inhibition of reactive oxygen species (ROS) by antioxidants inhibits the release of an autophagy marker in ectopic endometrial cells
by: Huixia Lu, et al.
Published: (2020)

ZnO NPs Impair the Viability and Function of Porcine Granulosa Cells Through Autophagy Regulated by ROS Production
by: Yifan Wang, et al.
Published: (2024)

Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa Cells
by: Xuan Zhang, et al.
Published: (2023)