Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways
Intestinal epithelial cells are an essential barrier in human gastrointestinal tract, and healing of epithelial wound is a key process in many intestinal diseases. α-Lipoic acid (ALA) was shown to have antioxidative and anti-inflammatory effects, which could be helpful in intestinal epithelial injur...
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| Format: | Book |
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Hindawi Limited,
2022-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_8b9d04d65b794b92b79779ce45e0070a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yu Yang |e author |
| 700 | 1 | 0 | |a Yong Xiao |e author |
| 700 | 1 | 0 | |a Yue Jiang |e author |
| 700 | 1 | 0 | |a Jiajun Luo |e author |
| 700 | 1 | 0 | |a Jingwen Yuan |e author |
| 700 | 1 | 0 | |a Junfeng Yan |e author |
| 700 | 1 | 0 | |a Qiang Tong |e author |
| 245 | 0 | 0 | |a Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways |
| 260 | |b Hindawi Limited, |c 2022-01-01T00:00:00Z. | ||
| 500 | |a 1466-1861 | ||
| 500 | |a 10.1155/2022/1894379 | ||
| 520 | |a Intestinal epithelial cells are an essential barrier in human gastrointestinal tract, and healing of epithelial wound is a key process in many intestinal diseases. α-Lipoic acid (ALA) was shown to have antioxidative and anti-inflammatory effects, which could be helpful in intestinal epithelial injury repair. The effects of ALA in human colonic epithelial cells NCM460 and human colorectal adenocarcinoma cells Caco-2 were studied. ALA significantly promoted NCM460 and Caco-2 migration, increased mucosal tight junction factors ZO-1 and OCLN expression, and ALA accelerated cell injury repair of both cells in wound healing assay. Western blot analysis indicated that ALA inhibited a variety of mitogen-activated protein kinase (MAPK) signaling pathways in the epithelial cells. In conclusion, ALA was beneficial to repair of intestinal epithelial injury by regulating MAPK signaling pathways. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Mediators of Inflammation, Vol 2022 (2022) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/2022/1894379 | |
| 787 | 0 | |n https://doaj.org/toc/1466-1861 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8b9d04d65b794b92b79779ce45e0070a |z Connect to this object online. |