Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc.

• Main Authors: Gonzalo P Barriga (Author), Fernando Villalón-Letelier (Author), Chantal L Márquez (Author), Eduardo A Bignon (Author), Rodrigo Acuña (Author), Breyan H Ross (Author), Octavio Monasterio (Author), Gonzalo A Mardones (Author), Simon E Vidal (Author), Nicole D Tischler (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes. Previously, we have shown that the Gc envelope glycoprotein is the viral fusion protein sharing characteristics...