Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

• Egile Nagusiak: Lili Ding (Egilea), Qiaoling Yang (Egilea), Eryun Zhang (Egilea), Yangmeng Wang (Egilea), Siming Sun (Egilea), Yingbo Yang (Egilea), Tong Tian (Egilea), Zhengcai Ju (Egilea), Linshan Jiang (Egilea), Xunjiang Wang (Egilea), Zhengtao Wang (Egilea), Wendong Huang (Egilea), Li Yang (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2021-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic di...