Clinical and Molecular Features of Anti-CENP-B Autoantibodies
Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantl...
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| Format: | Book |
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MDPI AG,
2021-09-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_8bb04d890a5543f89a7e83203097a7e1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rahul M. Prasad |e author |
| 700 | 1 | 0 | |a Alfonso Bellacosa |e author |
| 700 | 1 | 0 | |a Tim J. Yen |e author |
| 245 | 0 | 0 | |a Clinical and Molecular Features of Anti-CENP-B Autoantibodies |
| 260 | |b MDPI AG, |c 2021-09-01T00:00:00Z. | ||
| 500 | |a 10.3390/jmp2040024 | ||
| 500 | |a 2673-5261 | ||
| 520 | |a Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantly CENP-B, and are highly associated with rheumatologic disease (lcSSc/CREST syndrome). CENP-B autoantibodies have also been reported in cancer patients without symptoms of rheumatologic disease. The rise of oncoimmunotherapy stimulates inquiry into how and why anti-CENP-B autoantibodies are formed. In this review, we describe the clinical correlations between anti-CENP-B autoantibodies, rheumatologic disease, and cancer; the molecular features of CENP-B; possible explanations for autoantigenicity; and, finally, a possible mechanism for induction of autoantibody formation. | ||
| 546 | |a EN | ||
| 690 | |a centromere | ||
| 690 | |a CENP-B | ||
| 690 | |a scleroderma | ||
| 690 | |a autoimmunity | ||
| 690 | |a cancer | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Molecular Pathology, Vol 2, Iss 4, Pp 281-295 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/2673-5261/2/4/24 | |
| 787 | 0 | |n https://doaj.org/toc/2673-5261 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8bb04d890a5543f89a7e83203097a7e1 |z Connect to this object online. |