Daily oral supplementation of Hochu-Ekki-To prevents osteoclastic activation and bone loss in ovariectomized mice

• Main Authors: Shinsuke Ochiai (Author), Kazuya Tokumura (Author), Gyujin Park (Author), Kakeru Ozaki (Author), Tetsuhiro Horie (Author), Takanori Yamada (Author), Sayuki Iwahashi (Author), Kaname Ohta (Author), Hiroki Fusawa (Author), Yasuka Okayama (Author), Katsuyuki Kaneda (Author), Takashi Iezaki (Author), Eiichi Hinoi (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailty after an illness; however, its effects on metabolic bone diseases such as osteoporosis are not well known. We herein report that daily oral Hochu-Ekki-To administration significantly inhibits osteoclast activation as well as the reduction in bone volume in ovariectomized mice. Our results suggest that supplementation with Hochu-Ekki-To might be beneficial for the prophylaxis and treatment of metabolic bone diseases associated with abnormal osteoclast activation.

Item Description

1347-8613
10.1016/j.jphs.2020.09.007