Daily oral supplementation of Hochu-Ekki-To prevents osteoclastic activation and bone loss in ovariectomized mice
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailty after an illness; however, its effects on metabo...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Book |
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Elsevier,
2021-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_8bb19e32b3b8492a93d071b9d27caabe | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shinsuke Ochiai |e author |
| 700 | 1 | 0 | |a Kazuya Tokumura |e author |
| 700 | 1 | 0 | |a Gyujin Park |e author |
| 700 | 1 | 0 | |a Kakeru Ozaki |e author |
| 700 | 1 | 0 | |a Tetsuhiro Horie |e author |
| 700 | 1 | 0 | |a Takanori Yamada |e author |
| 700 | 1 | 0 | |a Sayuki Iwahashi |e author |
| 700 | 1 | 0 | |a Kaname Ohta |e author |
| 700 | 1 | 0 | |a Hiroki Fusawa |e author |
| 700 | 1 | 0 | |a Yasuka Okayama |e author |
| 700 | 1 | 0 | |a Katsuyuki Kaneda |e author |
| 700 | 1 | 0 | |a Takashi Iezaki |e author |
| 700 | 1 | 0 | |a Eiichi Hinoi |e author |
| 245 | 0 | 0 | |a Daily oral supplementation of Hochu-Ekki-To prevents osteoclastic activation and bone loss in ovariectomized mice |
| 260 | |b Elsevier, |c 2021-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2020.09.007 | ||
| 520 | |a Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailty after an illness; however, its effects on metabolic bone diseases such as osteoporosis are not well known. We herein report that daily oral Hochu-Ekki-To administration significantly inhibits osteoclast activation as well as the reduction in bone volume in ovariectomized mice. Our results suggest that supplementation with Hochu-Ekki-To might be beneficial for the prophylaxis and treatment of metabolic bone diseases associated with abnormal osteoclast activation. | ||
| 546 | |a EN | ||
| 690 | |a Osteoporosis | ||
| 690 | |a Osteoclast | ||
| 690 | |a Traditional herbal medicine | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 1-5 (2021) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861320300979 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8bb19e32b3b8492a93d071b9d27caabe |z Connect to this object online. |