Systemic Antibiotics as an Adjunct to Subgingival Debridement: A Network Meta-Analysis

This review aimed to evaluate the effectiveness of systemic antibiotics as adjunctive treatment to subgingival debridement in patients with periodontitis. Randomized controlled trials were included that assessed the effectiveness of systemic antibiotics in improving periodontal status, indicated by...

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Main Authors: Ainol Haniza Kherul Anuwar (Author), Roslan Saub (Author), Syarida Hasnur Safii (Author), Norintan Ab-Murat (Author), Mohd Syukri Mohd Taib (Author), Rokiah Mamikutty (Author), Chiu Wan Ng (Author)
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Published: MDPI AG, 2022-11-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Ainol Haniza Kherul Anuwar  |e author 
700 1 0 |a Roslan Saub  |e author 
700 1 0 |a Syarida Hasnur Safii  |e author 
700 1 0 |a Norintan Ab-Murat  |e author 
700 1 0 |a Mohd Syukri Mohd Taib  |e author 
700 1 0 |a Rokiah Mamikutty  |e author 
700 1 0 |a Chiu Wan Ng  |e author 
245 0 0 |a Systemic Antibiotics as an Adjunct to Subgingival Debridement: A Network Meta-Analysis 
260 |b MDPI AG,   |c 2022-11-01T00:00:00Z. 
500 |a 10.3390/antibiotics11121716 
500 |a 2079-6382 
520 |a This review aimed to evaluate the effectiveness of systemic antibiotics as adjunctive treatment to subgingival debridement in patients with periodontitis. Randomized controlled trials were included that assessed the effectiveness of systemic antibiotics in improving periodontal status, indicated by clinical attachment gain level, probable pocket depth reduction, and bleeding on probing reduction of patients with any form of periodontitis at any follow-up time. Network meta-analyses with a frequentist model using random effects was employed to synthesize the data. The relative effects were reported as mean difference with a 95% confidence interval. Subsequently, all treatments were ranked based on their P-scores. A total of 30 randomized controlled trials were included in this network meta-analyses. Minimally important clinical differences were observed following the adjunctive use of satranidazole, metronidazole, and clindamycin for clinical attachment gain level and probable pocket depth reduction. For bleeding on probing reduction, minimally important clinical differences were observed following the adjunctive use of metronidazole and a combination of amoxycillin and metronidazole. However, the network estimates were supported by evidence with certainty ranging from very low to high. Therefore, the findings of this network meta-analyses should be interpreted with caution. Moreover, the use of these antibiotics adjunct to subgingival debridement should be weighed against possible harm to avoid overuse and inappropriate use of these antibiotics in patients with periodontitis. 
546 |a EN 
690 |a evidence-based dentistry 
690 |a network meta-analysis 
690 |a antibacterial agents 
690 |a systemic antibiotics 
690 |a adjunct 
690 |a periodontal debridement 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antibiotics, Vol 11, Iss 12, p 1716 (2022) 
787 0 |n https://www.mdpi.com/2079-6382/11/12/1716 
787 0 |n https://doaj.org/toc/2079-6382 
856 4 1 |u https://doaj.org/article/8c10c55aecbd4a1eb0ac1bfc4dde045d  |z Connect to this object online.