Central odontogenic fibroma: Report of case with immunohistochemical study
Objectives: To report a case of central odontogenic fibroma (COF) with immunohistochemical study. Clinical Presentation: We describe a case of epithelium-rich type of COF in the posterior region of the mandible of a 39-year-old woman. Immunohistochemical examination showed the odontogenic epithelium...
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| Main Authors: | , , , |
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2013-01-01T00:00:00Z.
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| Summary: | Objectives: To report a case of central odontogenic fibroma (COF) with immunohistochemical study. Clinical Presentation: We describe a case of epithelium-rich type of COF in the posterior region of the mandible of a 39-year-old woman. Immunohistochemical examination showed the odontogenic epithelium to be positive for high-molecular-weight cytokeratins, vimentin and CD99, and negative for CAM5.2. The stroma contained some myofibroblasts and many fibroblast-like cells positive for CD99. Conclusion: Our immunohistochemical findings, and especially the positive expression of vimentin from the epithelial cells of COF suggests that these cells are primordial. Last but not least, the presence of a relative small number of myofibroblasts in the stroma justifies the non-aggressive behavior of the neoplasm and supports that a part of stromal collagen of COF is produced by these cells. |
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| Item Description: | 0970-9290 1998-3603 10.4103/0970-9290.127627 |