Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia

• Main Authors: Diying Shen (Author), Lixia Liu (Author), Xiaojun Xu (Author), Hua Song (Author), Jingying Zhang (Author), Weiqun Xu (Author), Fenying Zhao (Author), Juan Liang (Author), Chan Liao (Author), Yan Wang (Author), Tian Xia (Author), Chengcheng Wang (Author), Feng Lou (Author), Shanbo Cao (Author), Jiayue Qin (Author), Yongmin Tang (Author)
• Format: Book
• Published: BMC, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose The 5-year survival rate of children with acute lymphoblastic leukemia (ALL) is 85-90%, with a 10-15% rate of treatment failure. Next-generation sequencing (NGS) identified recurrent mutated genes in ALL that might alter the diagnosis, classification, prognostic stratification, trea...