The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer
Objective: Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC). The aim of the current study further attempts to evaluate the altered α 2,3-sialylation on the behavior of clear cell type EOC...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2018-04-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_8c1724081f334340b2c1ac4ff3ea5a9b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Pi-Lin Sung |e author |
| 700 | 1 | 0 | |a Kuo-Chang Wen |e author |
| 700 | 1 | 0 | |a Huann-Cheng Horng |e author |
| 700 | 1 | 0 | |a Chia-Ming Chang |e author |
| 700 | 1 | 0 | |a Yi-Jen Chen |e author |
| 700 | 1 | 0 | |a Wen-Ling Lee |e author |
| 700 | 1 | 0 | |a Peng-Hui Wang |e author |
| 245 | 0 | 0 | |a The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer |
| 260 | |b Elsevier, |c 2018-04-01T00:00:00Z. | ||
| 500 | |a 1028-4559 | ||
| 500 | |a 10.1016/j.tjog.2018.02.015 | ||
| 520 | |a Objective: Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC). The aim of the current study further attempts to evaluate the altered α 2,3-sialylation on the behavior of clear cell type EOC (C-EOC). Materials and methods: Immunohistochemistry staining, bioinformatics analysis and tissue array were used to disclose the clinical significance of over α2,3-sialylation in C-EOC. An α2,3 sialylation inhibitor, soyasaponin I (SsaI) was used to investigate the behavior change of the C-EOC cell line. Results: We reconfirmed that α2,3-sialylation, instead of α2,6- sialylation, was associated with late-stage C-EOC. Soyasaponin I could inhibit α2,3-sialylation of C-EOC cell lines and increase E-cadherin expression with subsequently suppressing migration of C-EOC cells. Conclusions: The current study demonstrated the important role of α2,3-linked sialylation in C-EOC and targeting of α2,3-linked sialylation might offer as a potential therapeutic strategy in the future. Keywords: α2,3-sialylation, Clear cell type, E-cadherin, Epithelial ovarian cancer, Soyasaponin I | ||
| 546 | |a EN | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Taiwanese Journal of Obstetrics & Gynecology, Vol 57, Iss 2, Pp 255-263 (2018) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1028455918300330 | |
| 787 | 0 | |n https://doaj.org/toc/1028-4559 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8c1724081f334340b2c1ac4ff3ea5a9b |z Connect to this object online. |