Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer

Mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cellular growth, development, survival, and metabolism through integration of diverse extracellular and intracellular stimuli. Additionally, mTOR is involved in interplay of signalling pathways that regulate apoptosis and auto...

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Main Authors: Suhail Ahmad Mir (Author), Ashraf Dar (Author), Saad Ali Alshehri (Author), Shadma Wahab (Author), Laraibah Hamid (Author), Mohammad Ali Abdullah Almoyad (Author), Tabasum Ali (Author), Ghulam Nabi Bader (Author)
Format: Book
Published: MDPI AG, 2023-07-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Suhail Ahmad Mir  |e author 
700 1 0 |a Ashraf Dar  |e author 
700 1 0 |a Saad Ali Alshehri  |e author 
700 1 0 |a Shadma Wahab  |e author 
700 1 0 |a Laraibah Hamid  |e author 
700 1 0 |a Mohammad Ali Abdullah Almoyad  |e author 
700 1 0 |a Tabasum Ali  |e author 
700 1 0 |a Ghulam Nabi Bader  |e author 
245 0 0 |a Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer 
260 |b MDPI AG,   |c 2023-07-01T00:00:00Z. 
500 |a 10.3390/ph16071004 
500 |a 1424-8247 
520 |a Mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cellular growth, development, survival, and metabolism through integration of diverse extracellular and intracellular stimuli. Additionally, mTOR is involved in interplay of signalling pathways that regulate apoptosis and autophagy. In cells, mTOR is assembled into two complexes, mTORC1 and mTORC2. While mTORC1 is regulated by energy consumption, protein intake, mechanical stimuli, and growth factors, mTORC2 is regulated by insulin-like growth factor-1 receptor (IGF-1R), and epidermal growth factor receptor (EGFR). mTOR signalling pathways are considered the hallmark in cancer due to their dysregulation in approximately 70% of cancers. Through downstream regulators, ribosomal protein S6 kinase β-1 (S6K1) and eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1), mTORC1 influences various anabolic and catabolic processes in the cell. In recent years, several mTOR inhibitors have been developed with the aim of treating different cancers. In this review, we will explore the current developments in the mTOR signalling pathway and its importance for being targeted by various inhibitors in anti-cancer therapeutics. 
546 |a EN 
690 |a cancer 
690 |a regulation of mTOR signalling pathway 
690 |a mTORC1/2 
690 |a mTOR inhibitors 
690 |a rapamycin 
690 |a Medicine 
690 |a R 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceuticals, Vol 16, Iss 7, p 1004 (2023) 
787 0 |n https://www.mdpi.com/1424-8247/16/7/1004 
787 0 |n https://doaj.org/toc/1424-8247 
856 4 1 |u https://doaj.org/article/8c2bae4e5d174f988fba4c0f827e14d7  |z Connect to this object online.