Combined docking and machine learning identify key molecular determinants of ligand pharmacological activity on β2 adrenoceptor
Abstract G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug discovery is to understand what determines the agonism or antagonism of ligands that bind them. Ligands exert their action via the interactions in the ligand binding pocke...
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Main Authors: | , , , , , , , , , , , , , |
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Formato: | Libro |
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Wiley,
2022-10-01T00:00:00Z.
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Acceso en liña: | Connect to this object online. |
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