In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog

• Príomhchruthaitheoirí: Claudia A. Soto (Údar), Huang-Chi Du (Údar), Robert G. Fox (Údar), Taegyun Yang (Údar), James Hooson (Údar), Noelle C. Anastasio (Údar), Scott R. Gilbertson (Údar), Kathryn A. Cunningham (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Hypofunction of the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) has been implicated in a variety of disorders including substance use disorders. As such, approaches to enhance 5-HT2CR signaling display therapeutic potential. In the present study, we show that disruption of the 5-HT2CR interaction wit...