Iron-Reduced Graphene Oxide Core-Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light
Core-shell micro/nanomotors have garnered significant interest in biomedicine owing to their versatile task-performing capabilities. However, their effectiveness for photothermal therapy (PTT) still faces challenges because of their poor tumor accumulation, lower light-to-heat conversion, and due to...
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MDPI AG,
2024-06-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_8c3d2d5b4fe34576bca65c34e42a890f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Orlando Donoso-González |e author |
| 700 | 1 | 0 | |a Ana L. Riveros |e author |
| 700 | 1 | 0 | |a José F. Marco |e author |
| 700 | 1 | 0 | |a Diego Venegas-Yazigi |e author |
| 700 | 1 | 0 | |a Verónica Paredes-García |e author |
| 700 | 1 | 0 | |a Camila F. Olguín |e author |
| 700 | 1 | 0 | |a Cristina Mayorga-Lobos |e author |
| 700 | 1 | 0 | |a Lorena Lobos-González |e author |
| 700 | 1 | 0 | |a Felipe Franco-Campos |e author |
| 700 | 1 | 0 | |a Joseph Wang |e author |
| 700 | 1 | 0 | |a Marcelo J. Kogan |e author |
| 700 | 1 | 0 | |a Soledad Bollo |e author |
| 700 | 1 | 0 | |a Claudia Yañez |e author |
| 700 | 1 | 0 | |a Daniela F. Báez |e author |
| 245 | 0 | 0 | |a Iron-Reduced Graphene Oxide Core-Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light |
| 260 | |b MDPI AG, |c 2024-06-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics16070856 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a Core-shell micro/nanomotors have garnered significant interest in biomedicine owing to their versatile task-performing capabilities. However, their effectiveness for photothermal therapy (PTT) still faces challenges because of their poor tumor accumulation, lower light-to-heat conversion, and due to the limited penetration of near-infrared (NIR) light. In this study, we present a novel core-shell micromotor that combines magnetic and photothermal properties. It is synthesized via the template-assisted electrodeposition of iron (Fe) and reduced graphene oxide (rGO) on a microtubular pore-shaped membrane. The resulting Fe-rGO micromotor consists of a core of oval-shaped zero-valent iron nanoparticles with large magnetization. At the same time, the outer layer has a uniform reduced graphene oxide (rGO) topography. Combined, these Fe-rGO core-shell micromotors respond to magnetic forces and near-infrared (NIR) light (1064 nm), achieving a remarkable photothermal conversion efficiency of 78% at a concentration of 434 µg mL<sup>−1</sup>. They can also carry doxorubicin (DOX) and rapidly release it upon NIR irradiation. Additionally, preliminary results regarding the biocompatibility of these micromotors through in vitro tests on a 3D breast cancer model demonstrate low cytotoxicity and strong accumulation. These promising results suggest that such Fe-rGO core-shell micromotors could hold great potential for combined photothermal therapy. | ||
| 546 | |a EN | ||
| 690 | |a core-shell micromotors | ||
| 690 | |a magnetic guidance | ||
| 690 | |a photothermal effect | ||
| 690 | |a reduced graphene oxide | ||
| 690 | |a photothermal therapy | ||
| 690 | |a cancer | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 16, Iss 7, p 856 (2024) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/16/7/856 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8c3d2d5b4fe34576bca65c34e42a890f |z Connect to this object online. |