Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer

• Main Authors: Wenmin Cheng (Author), Heng Zhao (Author), Honghao Yu (Author), Jige Xin (Author), Jia Wang (Author), Luyao Zeng (Author), Zaimei Yuan (Author), Yubo Qing (Author), Honghui Li (Author), Baoyu Jia (Author), Cejun Yang (Author), Youfeng Shen (Author), Lu Zhao (Author), Weirong Pan (Author), Hong-Ye Zhao (Author), Wei Wang (Author), Hong-Jiang Wei (Author)
• Format: Book
• Published: BMC, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background α1,3-Galactosyltransferase (GGTA1) is essential for the biosynthesis of glycoproteins and therefore a simple and effective target for disrupting the expression of galactose α-1,3-galactose epitopes, which mediate hyperacute rejection (HAR) in xenotransplantation. Miniature pigs a...