Feasibility of fine needle aspiration for diagnosis of b-cell lymphoma of the thyroid: a case series and review of the literature

Abstract Background Primary thyroid lymphoma (PTL) is a rare cancer accounting for approximately 5% of thyroid malignancies. Historically, incisional biopsy has been the gold standard for definitive diagnosis of PTL, however, the use of cell block as an adjunct to fine needle aspiration (FNA) provid...

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Main Authors: Alexander D. Karabachev (Author), William J. Brundage (Author), Mirabelle B. Sajisevi (Author), Allison L. Ciolino (Author)
Format: Book
Published: BMC, 2023-05-01T00:00:00Z.
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100 1 0 |a Alexander D. Karabachev  |e author 
700 1 0 |a William J. Brundage  |e author 
700 1 0 |a Mirabelle B. Sajisevi  |e author 
700 1 0 |a Allison L. Ciolino  |e author 
245 0 0 |a Feasibility of fine needle aspiration for diagnosis of b-cell lymphoma of the thyroid: a case series and review of the literature 
260 |b BMC,   |c 2023-05-01T00:00:00Z. 
500 |a 10.1186/s13000-023-01346-4 
500 |a 1746-1596 
520 |a Abstract Background Primary thyroid lymphoma (PTL) is a rare cancer accounting for approximately 5% of thyroid malignancies. Historically, incisional biopsy has been the gold standard for definitive diagnosis of PTL, however, the use of cell block as an adjunct to fine needle aspiration (FNA) provides a high sensitivity and specificity for diagnosis and classification. Methods Three patients presented with a symptomatic enlarging thyroid mass. Patient 1 underwent incisional biopsy under general anesthesia, Patient 2 underwent core needle biopsy to avoid high risk intubation, and Patient 3 underwent fine needle aspiration alone with the use of cell block. Results All patients were diagnosed with a fully classified non-Hodgkin's lymphoma using immunohistochemistry, flow cytometry, and fluorescence in situ hybridization (FISH) analysis. Conclusions FNA for diagnosis of some subtypes of PTL is feasible and preferred in cases that are particularly high risk for general anesthesia. This minimally invasive technique is safe and cost effective as it avoids expenses associated with operative intervention. 
546 |a EN 
690 |a Pathology 
690 |a Thyroid cancer-clinical 
690 |a Thyroid lymphoma 
690 |a Fine needle aspiration 
690 |a Cell block 
690 |a Diagnosis 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Diagnostic Pathology, Vol 18, Iss 1, Pp 1-6 (2023) 
787 0 |n https://doi.org/10.1186/s13000-023-01346-4 
787 0 |n https://doaj.org/toc/1746-1596 
856 4 1 |u https://doaj.org/article/8c5a149f035d4db6942bf6242cd8cee5  |z Connect to this object online.