Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals
We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenger RNA in mice. α-L-LNA represents the α-anomer of e...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2012-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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