Morin mitigate diethyl phthalate and bisphenol s - Induced hematotoxicity in rats model by abrogating oxidative stress

• Main Authors: Ofem Effiom Eteng (Author), Ceaser Antiya Moses (Author), Chukwuka Uzoamaka Ogbonna (Author), Abdulwasiu Oladokun Adeleye (Author), Emmanuel Ifeanyichukwu Ugwor (Author), Adewale Segun James (Author), Esther Olamide Oladimeji (Author), Adio Jamiu Akamo (Author), Iwara Arikpo Iwara (Author), Friday Effiong Uboh (Author), Mbeh Eteng (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Endocrine disruptors affect biological systems, some as neglected home producing toxicity (NHPT). We investigated the effect of morin on diethyl phthalate (DEP) and bisphenol S (BPS)-induced hematotoxicity and oxidative stress using a rat model. Rats were exposed to DEP (50 μg/kg) and BPS (200 μg/kg) and treated with morin (25 and 50 mg/kg) by oral gavage for twenty-one days. Afterwards, they were sacrificed. Morin treatment significantly (p < 0.05) protected red blood cells and plasma membrane architecture by abolishing the DEP+BPS-induced decrease in the activity of all the hematological indices. Co-treatment with morin remarkably (p < 0.05) reversed DEP+BPS-induced decreases in glutathione levels, CAT, GPx, and SOD activities in red blood cells, while attenuating DEP+BPS mediated increase in hemato-oxidative damage markers (MDA and NO levels). Collectively, the different acute doses of morin might avert DEP and BPS-mediated hematotoxicity dysfunctions via its antioxidant, free-radical scavenging effect.

Item Description

2667-1425
10.1016/j.prmcm.2022.100154