Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury

• Main Authors: Akihisa Kamiya (Author), Takuji Machida (Author), Megumi Hirano (Author), Maiko Machida (Author), Saki Shiga (Author), Naoya Hamaue (Author), Masahiko Hirafuji (Author), Kenji Iizuka (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effects of cyclophosphamide on 5-hydroxytryptamine (5-HT) synthesis in the intestinal tissue of rats were investigated. Rats received 120 mg/kg cyclophosphamide intraperitoneally as a single administration, and kaolin and food intake was measured by an automatic monitoring apparatus. Ileal tissu...