Simultaneous determination of ezetimibe and simvastatin in rat plasma by stable-isotope dilution LC-ESIâMS/MS and its application to a pharmacokinetic study

• প্রধান লেখক: Sireesha R. Karanam (Author), Prakash Katakam (Author), Babu R. Chandu (Author), Nagiat T. Hwisa (Author), Shanta K. Adiki (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2014-08-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A simple, sensitive and specific liquid chromatographyâtandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma. The deuterium isotopes: ezetimibe d4 and simvastatin d6 were used as internal standards for ezetimibe and simvastatin, resp...