Intratumoral delivered novel circular mRNA encoding cytokines for immune modulation and cancer therapy

• Main Authors: Jiali Yang (Author), Jiafeng Zhu (Author), Jiaojiao Sun (Author), Yiyun Chen (Author), Yaran Du (Author), Yiling Tan (Author), Linpeng Wu (Author), Mengting Zhai (Author), Lixiang Wei (Author), Na Li (Author), Ke Huang (Author), Qiangbo Hou (Author), Zhenbo Tong (Author), Andreas Bechthold (Author), Hao Tian (Author), Zhenhua Sun (Author), Chijian Zuo (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The success of the two mRNA vaccines developed by Moderna and BioNTech during the COVID-19 pandemic increased research interest into the application of mRNA technologies. Compared with the canonical linear mRNA used in these vaccines, circular mRNA has been found to mediate more potent and durable p...