A randomized trial evaluating the association between related gene polymorphism and nausea and vomiting induced by cisplatin multi-day chemotherapy
Abstract Purpose We aim to investigate the correlation between gene polymorphisms and cisplatin chemotherapy-induced nausea and vomiting (CINV), which was prevented by olanzapine or aprepitant triple antiemetic regimen. Methods Before chemotherapy, the blood samples of 89 malignant tumor patients wh...
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2023-11-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_8cb7e45f21e84d29a0158ab0f1912d0e | ||
042 | |a dc | ||
100 | 1 | 0 | |a Yilan Jin |e author |
700 | 1 | 0 | |a Feng Chen |e author |
700 | 1 | 0 | |a Juan Zhao |e author |
700 | 1 | 0 | |a Ying Jiang |e author |
700 | 1 | 0 | |a Gaowa Jin |e author |
700 | 1 | 0 | |a Zewei Zhang |e author |
700 | 1 | 0 | |a Quanfu Li |e author |
245 | 0 | 0 | |a A randomized trial evaluating the association between related gene polymorphism and nausea and vomiting induced by cisplatin multi-day chemotherapy |
260 | |b BMC, |c 2023-11-01T00:00:00Z. | ||
500 | |a 10.1186/s12920-023-01719-0 | ||
500 | |a 1755-8794 | ||
520 | |a Abstract Purpose We aim to investigate the correlation between gene polymorphisms and cisplatin chemotherapy-induced nausea and vomiting (CINV), which was prevented by olanzapine or aprepitant triple antiemetic regimen. Methods Before chemotherapy, the blood samples of 89 malignant tumor patients who received multi-day chemotherapy with cisplatin were collected for sequencing and typing. As there were duplicate patients enrolled in different chemotherapy cycles, there were a total of 190 cases. The patients were divided into two groups randomly, who received the triple antiemetic regimen of olanzapine or aprepitant combined with 5-HT3RA and dexamethasone. The main evaluation indicators were the total protection (TP) rate in the acute phase (0-24 h), the delayed phase (25-120 h) and the overall phase (0-120 h). Results Univariate analysis was performed on genetic loci that reached H-W balance with TP. In the olanzapine group, increased TP in the acute phase was associated with HTR3A rs1176719 non-GG (P < 0.05) genotype etc. Increased TP in the delayed phase was associated with HTR3A rs1176719 non-GG (P < 0.05) genotype etc. In the aprepitant group, increased TP in the acute phase was associated with the MTHFR rs1801131 TT (P < 0.05) genotype etc. Increased TP in the delayed phase was associated with HTR3A rs1062613 CC (P < 0.05) genetype ect. Multivariate Logistic regression analysis showed that HTR3B rs7943062GG (P < 0.05) genotype etc. were correlated with increased TP in the delayed phase. MTHFR rs1801131TT genotype was associated with increased TP in the acute phase (P < 0.05) and delayed phase (P < 0.05). Conclusion This study found that gene polymorphisms, including HTR3B (rs1062613, rs1176719, rs2276303), HTR3B (rs45460698, rs7943062), HTR3C (rs6766410), ERCC1 (rs3212986), ERCC4 (rs744154) and MTHFR(rs1801131), may be independent prognostic factors for CINV. | ||
546 | |a EN | ||
690 | |a CINV | ||
690 | |a Gene Polymorphism | ||
690 | |a Cisplatin | ||
690 | |a Multi-day chemotherapy | ||
690 | |a Internal medicine | ||
690 | |a RC31-1245 | ||
690 | |a Genetics | ||
690 | |a QH426-470 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n BMC Medical Genomics, Vol 16, Iss 1, Pp 1-10 (2023) | |
787 | 0 | |n https://doi.org/10.1186/s12920-023-01719-0 | |
787 | 0 | |n https://doaj.org/toc/1755-8794 | |
856 | 4 | 1 | |u https://doaj.org/article/8cb7e45f21e84d29a0158ab0f1912d0e |z Connect to this object online. |