Review Drug safety: focus on long-term therapy with proton pump inhibitors. Probable side effects

Currently, an important component of rational pharmacotherapy is drug safety. Proton pump inhibitors (PPIs) are the most effective drugs for the treatment of acid-related diseases. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clin...

Full description

Saved in:
Bibliographic Details
Main Author: Dmitry I. Trukhan (Author)
Format: Book
Published: LLC "MEDIAFORMAT", 2024-01-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_8cce9a3c02b94c2f8b5b70fb11597dd2
042 |a dc 
100 1 0 |a Dmitry I. Trukhan  |e author 
245 0 0 |a Review Drug safety: focus on long-term therapy with proton pump inhibitors. Probable side effects 
260 |b LLC "MEDIAFORMAT",   |c 2024-01-01T00:00:00Z. 
500 |a 10.47407/kr2023.5.1.00360 
500 |a 2713-2552 
520 |a Currently, an important component of rational pharmacotherapy is drug safety. Proton pump inhibitors (PPIs) are the most effective drugs for the treatment of acid-related diseases. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the connections between PPIs and a number of diseases/conditions, but in the domestic literature there are no reviews on the safety of PPIs during long-term use. A search was conducted in the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to November 15, 2023. However, long-term use of PPIs is associated with numerous side effects, and it is not possible to discuss all of them in detail in one review. This review examines the most likely side effects associated with long-term PPI therapy: the development of infections, increased risk of fractures and kidney pathology. The association of long-term use of PPIs with the development of these side effects is not denied or questioned in recent reviews. 
546 |a EN 
546 |a RU 
690 |a proton pump inhibitors 
690 |a drug safety 
690 |a probable side effects 
690 |a clostridium difficile infection 
690 |a community-acquired pneumonia 
690 |a novel coronavirus infection (covid-19) 
690 |a osteoporosis 
690 |a hip fracture 
690 |a vertebral fracture 
690 |a wrist fracture 
690 |a acute interstitial nephritis 
690 |a acute kidney injury 
690 |a chronic kidney disease 
690 |a terminal stage renal failure 
690 |a Internal medicine 
690 |a RC31-1245 
655 7 |a article  |2 local 
786 0 |n Клинический разбор в общей медицине, Vol 5, Iss 1, Pp 48-56 (2024) 
787 0 |n https://klin-razbor.ru/en/archive/2024/vol-5-1-2024/review-drug-safety-focus-on-long-term-therapy-with-proton-pump-inhibitors-probable-side-effects_6677/?element 
787 0 |n https://doaj.org/toc/2713-2552 
856 4 1 |u https://doaj.org/article/8cce9a3c02b94c2f8b5b70fb11597dd2  |z Connect to this object online.