Evaluation of the regenerative potential of 25&#x0025; doxycycline-loaded biodegradable membrane <i> vs</i> biodegradable membrane alone in the treatment of human periodontal infrabony defects: A clinical and radiological study

• Main Authors: Chaturvedi Rashi (Author), Gill Amarjit (Author), Sikri Poonam (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0970-9290; 1998-3603
• Keywords: Antimicrobial agents; host modulation; infection; microbial colonization; regeneration; Dentistry; RK1-715
• Source: Indian Journal of Dental Research, Vol 19, Iss 2, Pp 116-123 (2008)

<b>Background:</b> Microbial colonization of the barrier membranes used for guided tissue regeneration is inevitable and can lead to delayed healing. <b> Aims:</b> Antimicrobial coating of the membrane with 25&#x0025; doxycycline paste has been attempted to prevent infection and achieve enhanced regeneration in periodontal infrabony defects. <b> Materials and Methods:</b> Twenty-four patients with 2-walled or 3-walled infrabony defects were selected and randomly divided into two equal groups. Infrabony defects of group A were treated with a biodegradable membrane coated with 25&#x0025; doxycycline while those of group B were treated with membrane alone. Clinical assessment of probing depth and attachment level and radiographic evaluation of the defect depth was done preoperatively and at 12 and 24 weeks postoperatively. <b> Statistical Analysis:</b> The relative efficacy of the two treatment modalities were evaluated using the paired Student&#x2032;s <i> t-</i> test and the comparative evaluation between the two groups was done using the independent Student&#x2032;s <i> t</i> -test. <b> Results:</b> Both the groups exhibited a highly significant reduction in probing depth and gain in clinical attachment level and linear bone fill at the end of 24 weeks. Comparative evaluation between the two study groups revealed a significant reduction in probing depth (<i> P</i> = 0.016^FNx01 ) and linear bone fill (<i> P</i> = 0.02^FNx01 ) in group A as compared to group B. Mean gain in attachment level was greater for group A than for group B but the difference was statistically nonsignificant (<i> P</i> = 0.065^NS ). <b> Conclusions:</b> The results suggest that doxycycline is beneficial in reducing membrane-associated infection and can potentiate regeneration through host modulation.