Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

• Main Authors: Fengyi Zhao (Author), Xu Sun (Author), Wen Lu (Author), Li Xu (Author), Jiuzhou Shi (Author), Shilong Yang (Author), Mengyi Zhou (Author), Fan Su (Author), Feng Lin (Author), Fuliang Cao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix),...